If someone is run-down, they are tired or slightly ill. 疲惫的; 略感不适的
adjective [原级]破败的;衰弱的
When 23-year-old Marilyn Brown started to feel run-down last December, it never occurred to her that she could have tuberculosis. 当23岁的玛丽莲•布朗去年12月开始感到疲惫的时候,她未曾想到她会得肺结核。